Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.

These results further showed that the findings of highly significant interaction effects between EBV and the two human HLA genetic variants were robust to the assumed genetic models, i.e., both the additive model and the recessive model (comparing the individuals carrying only susceptible alleles versus those carrying protective alleles).

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Both the original and replication studies, as well as the pooled study, revealed significant direct effects and small, statistically non-significant or weakly significant indirect effects.

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