We also confirmed highly significant correlations of the patterns of transcriptomic changes (FC of each gene) between cells with homozygous and heterozygous variants ( Figure S18 , p < 2.2 × 10 −16 for both chr7:g.26200781C>T and chr22:g.19179942C>T lines).
In contrast, there was no or only modestly significant association when TADs in peripheral tissues were used, with a statistically significant difference in ORs between brain and stem cells and peripheral tissues ( Figure 1 E, p = 2.72 × 10 −5 , two-tailed Wilcoxon rank-sum test).
On the other hand, the heritability of other phenotypes 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 was not significantly enriched in the promoter regions of nominally significant TADs.