Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt-Jakob disease.

There was a significant trend that the segmented volumes increased as the visual grade aggravated (minimal involvement: 29.6 ± 18.1 mm 3 ; moderate involvement: 45.4 ± 30.4 mm 3 ; extensive involvement: mean 112.9 ± 73.2 mm 3 ) ( P < 0.001) (Fig. 5 a).

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