Focused ultrasound ablation of melanoma with boiling histotripsy yields abscopal tumor control and antigen-dependent dendritic cell activation.

For contralateral tumors not directly exposed to BH, multi-variate statistical analysis of the modeled growth curves showed a strong trend toward growth control (Figure 1 F-G), with the AUC metric (Figure 1 H) yielding a significant reduction in integrated contralateral tumor burden.

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When applied to the ipsilateral tumor in a bilateral setting at 14 days post-inoculation, our BH regimen (Figure 1 A; FUS parameters provided in Figure S1 ) significantly improved survival (Figure 1 B) and controlled ipsilateral tumors (Figure 1 C-E), with the “area under the curve” (AUC) metric showing a highly significant ~40% reduction in integrated tumor burden (Figure 1 E).

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