Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation.

As the hepatocytes carry out the main metabolic activities of the liver, it was expected that the undifferentiated liver organoids (primarily ductal cells) would have lower induction levels of the CYP enzymes than the differentiated liver organoids (containing hepatocytes) after AFB 1 treatment. This was the case for both CYP enzymes examined; however, because the induction of CYP1A2 in differentiated liver had high variability, the difference did not reach statistical significance.

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