The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.

Besides, the systolic left ventricular posterior wall (LVPW) and the diastolic LVPW of TTN +/- showed a trend of thickening.

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Results For the two-month-old TTN +/- mice, serum glutamic-oxalacetic transaminase (AST), lactic dehydrogenase (LDH), and creatine kinase (CK) were significantly increased, the diastolic Left Ventricular Systolic Anterior Wall (LVAW), and the LV mass markedly rose, with the left ventricular volume displaying an increasing trend and Ejection Fraction (EF) and Fractional Shortening (FS) showing a decreasing trend.

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