Assessing the impact of public funding in alleviating participant reduction and improving the retention rate in methadone maintenance treatment clinics in Taiwan: an interrupted time series analysis.

For MMT clinics receiving PMES only, before the intervention, there was a decreasing trend in the monthly average number of daily participants in every scale of the MMT clinics, with a baseline slope ranging from − 0.23 to − 1.98 ( p < 0.01 for all).

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For MMT clinics receiving PMES only, there was an increasing trend before the intervention in the average 3-month retention rate in the overall MMT clinics (baseline slope = 0.07%, p = 0.02), with similar point estimates failing to reach statistical significance in individual scales of MMT clinics.

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If autocorrelation was not adjusted for in the SITSA, results remained similar except that several slope change estimates failed to reach statistical significance (more details in Supplementary Table S 2 ).

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