Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury.

However, a slight trend suggestive of reduced Gfap -upregulation at 3 dpi was observed in Müller cells from ischemic retinas treated with FH variants compared to those treated with EGFP alone, an effect that diminished at 14 dpi (Fig. 2 E).

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Although all morphometric parameters tested are closer to 1 (i.e., equal to the values in the non-ischemic control eye), the therapeutic benefits of AAV_FH1-4^19-20 and AAV_FH1-7^19-20 did not reach statistical significance compared to ischemic eyes treated with AAV_EGFP (Fig. 4 C, D ).

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