Sequential versus Standard Triple Therapy for First-Line <i>Helicobacter pylori</i> Eradication: An Update.

Although there seemed to be a similar proportion in the nitroimidazole-resistance cure rates (83% versus 82%) as well as in the dual resistance group (62% versus 54%), these apparent advantages of SEQ did not reach statistical significance when compared to STT.

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For the length of the STT regimen, the previously reported benefit of SEQ when compared to 10-day STT ( Figure 9 ) could not be demonstrated in the most recent studies (2010 onwards), in which the efficacy of SEQ showed a marginally significant statistical advantage, but it was potentially equivalent to that of 10-day STT at a clinical level. 2.6.3.

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When including only studies where SEQ and STT were both given for 10 days, the alleged benefit offered by SEQ was reduced to marginal significance in the studies using standard acid inhibition.

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