−0.246 ± 0.497, p = 0.041), while the difference between PI*MR COPD and pre-COPD and between pre-COPD and healthy subjects in their annual decline in FEV 1 , FEV 1 /FVC and DLCO did not reach statistical significance ( Figure 6 ).
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Alpha-1 Antitrypsin PI M Heterozygotes with Rare Variants: Do They Need a Clinical and Functional Follow-Up?
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