[ 33 ], CXCL12 (stromal cell-derived factor-1, SDF-1) showed a trend of activating M1 macrophages more effectively, without reaching significance.
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Three-Dimensionally Cultured Jaw Periosteal Cells Attenuate Macrophage Activation of CD4<sup>+</sup> T Cells and Inhibit Osteoclastogenesis.
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In contrast, the expression of CCL3 , CD163 and VEGFA genes showed an increasing trend in the 3DJPC/3DOBJPC-M2 groups when compared with the cell-free controls TCP/OBTCP-M2.
The expression level of pro-inflammatory TNF-α in co-cultured M2 macrophages also showed a decreasing trend in the 3DJPC/3DOBJPC-M2 groups compared to the control groups.