Seroepidemiology of Herpes Simplex Viruses Type 1 and 2 in Pregnant Women in Croatia.

Furthermore, the results suggested an increasing trend in the incidence of neonatal herpes in Europe in contrast to the decreasing trend of HSV-2 seroprevalence, perhaps reflecting the increasing trend of genital herpes caused by HSV-1 in this region, and increasing maternal age associated with higher HSV-2 seroprevalence [ 15 ].

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The HSV-1 seroprevalence was stable up to 40 years (70.0 and 68.3%, respectively), with an increase to 86.1%, but this difference did not reach statistical significance.

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The results of the risk analysis ( Table 3 , Table 4 and Table 5 ) showed that older age was a significant risk factor for HSV-2 IgG seropositivity, while a marginal significance was observed for HSV-1 IgG seropositivity.

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