Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level.

Sci Rep · 2024 · PMC10891043 · PMID 38396014

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did not reach statistical significanceno p-value reported

Hence, our initial observations did not reach statistical significance but clearly showed similar trends to previous studies that associate active UC with DNA hypomethylation 15 .

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