Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancer.

4e ) showed a strong trend towards decreased expression, which was similar to the findings with AR-upregulated pca-protein-coding genes (paired T test P value = 0.22, Supplementary Fig. 3e ) and the AR VIPER score (paired T test P value = 0.13, Supplementary Fig. 3f ) from the original studies 30 , suggesting that lineage plasticity due to treatment resistance may also alter the landscape of AR-regulated lncRNAs.

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