The decrease in nuclear abundance of RELA, which is involved in canonical NFKB signaling ( 47 ), did not reach statistical significance ( Fig. 6 , A and B , p = 0.07).
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Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells.
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The two most highly significant pathway alterations, which also had the two largest absolute normalized enrichment scores, were downregulations in “TNFA signaling via NFKB” and “MYC targets V1.” CHO 2E2 cells also exhibited downregulations in pathways related to protein translation and glycolysis, among others.