Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters.

Viruses · 2024 · PMC10891789 · PMID 38400021

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

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highly significantp < 0.001actually significant

H1N1 given 48 h prior to SARS-CoV-2 almost completely abrogated SARS-CoV-2-typical weight loss in both sexes, beginning at 2 dpi, and increasing to highly significant protection ( p < 0.001) from 5 dpi onwards.

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did not reach statistical significanceno p-value reported

IFN-γ expression was relatively higher at 2 dpi in the dual-infected group (comparable to expression 4 dpi in singly infected H1N1 hamsters) compared to singly infected animals; however, this did not reach statistical significance.

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