Serotype Distribution and Antimicrobial Susceptibility Pattern of <i>Streptococcus pneumoniae</i> in COVID-19 Pandemic Era in Brazil.

The analysis of the cumulative percentage obtained by summing the serotypes corresponding to the different vaccine formulations in each age group showed a trend towards increased protection against IPD, caused by the additional serotypes included in these higher-valence vaccines, independently of the age group or period.

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We also observed an increasing trend towards higher levels of MIC values (≥2.0 μg/mL) for both antimicrobials, especially when analyzing the COVID-19 year of 2021 (24.4% for penicillin) and 2022 (39.5% for penicillin and 18.5% for ceftriaxone) ( Figure 2 A,B).

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