Barely Significant
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Imiquimod Solubility in Different Solvents: An Interpretative Approach.

Pharmaceutics · 2024 · PMC10893280 · PMID 38399335

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a clear trendno p-value reported
Although solubility values in H 2 O at 30 and 25 °C were not statistically different ( p = 0.44), a clear trend of decreasing solubility is observed as the temperature drops, so much so that it is not possible to experimentally determine the solubility at 4 °C as this is below the LOQ ( Table 2 ).

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