Impact of Difelikefalin on the Health-Related Quality of Life of Haemodialysis Patients with Moderate-To-Severe Chronic Kidney Disease-Associated Pruritus: A Single-Arm Intervention Trial.

affected by pruritus had been significantly reduced after treatment; duration − 1.5 (95% CI − 1.7, − 1.3; p < 0.001), indicating that patients transitioned from being bothered by pruritus for up to 18 h per day to a maximum of 6–12 h per day; degree − 1.3 (95% CI − 1.4, − 1.1; p < 0.001), implying a significant trend from moderate/severe to mild pruritus; and direction − 1.7 (95% CI − 1.9, − 1.6; p < 0.001), indicating a significant improvement in pruritus when compared with baseline (Table 2 ).

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