Similar to the findings with CyTOF analysis, a trend for a reduction in the cell clusters expressing signatures of activation or exhaustion was observed, although this did not reach statistical significance, and a reciprocal statistically significant increase in resting or naïve cells (CCR7 + Sell + ) (Fig. 3d ).
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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.
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