Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

J Med Chem · 2024 · PMC10895668 · PMID 38330051

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a clear trendno p-value reported

A clear trend of decreasing activity (from pIC 50 7.1 for 11 to pIC 50 < 4.2 for 21d and 21f ) can be correlated with the increasing size of the R 2 substituent.

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