Integrative single-cell expression and functional studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cells.

The highest expression of HIF1A and HIF2A ( EPAS1 ) was observed in inv(16) and t (8;21) samples, both core binding factor (CBF)‐rearranged AMLs, whereas MLLr samples showed a trend for the lowest expression (Figure 1B ), especially in TARGET and Leucegene.

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