The Therapeutic Landscape in Chronic Cough.

Although the primary endpoint of awake cough frequency did not reach statistical significance, preplanned subgroup analysis in patients with a cough frequency ≥20 coughs per hour (80% of patients) and those with greater than the median cough frequency (≥32 coughs per hour, 50% of patients) exhibited significant improvements versus placebo for all doses tested [ 55 ].

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The reduction in daytime cough frequency of 32% over placebo (primary endpoint) was not quite statistically significant but taste adverse effects were only reported in 6.4% of patients.

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