A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.

In this experiment, treatment with 2.5 nM TG trended toward slightly diminished EdU incorporation in Chop −/− cells but not in wild-type cells—though this trend did not reach statistical significance—while 50 nM TG almost entirely prevented EdU incorporation in Chop −/− cells yet allowed for modest but significant incorporation in w.t. cells (Fig. 1B ).

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