Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice.

2.0 ± 0.2 mm Hg, n = 6; Supplementary Table S1 ), as previously described in younger mice ( Labbé et al., 2022 ); SHAM-KD mice also exhibited mild LV systolic dysfunction characterized by a significant decrease ( p < 0.05) in LVFS ( Figure 4B ; Table 1 ), a strong trend ( p = 0.0635) towards a reduction in LVEF ( Figure 4B ; Table 1 ), and a significant decrease ( p < 0.01) in LV lateral and septal wall contractility ( Figure 4B ; Table 1 ).

also in 5,725 other papers