A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models.

Moreover, Fc–IL-2, but not mIL-2, increased the percentage of IFN-γ + CD4 + Tconv and CD8 + T cells ( Figure 3, F and G ) compared with controls; however, the latter did not reach statistical significance ( P = 0.176).

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