Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target.

Regarding anatomical defects, both male and female mice showed reduced myelination, although females did not reach statistical significance (fig.

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When we tested for anxiety behavior by the elevated plus maze (EPM) task, we only found a nonsignificant trend versus increased anxiety in JB1-treated mice, as assessed by the decreased number of entries and the decreased time spent in the open arms of the maze (fig.

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