Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade.

Notably, the combination of anti-PD-1 and anti-IL-10 induced significantly more tumor cell apoptosis than IgG control (p = 0.03), while the difference between either of the individual treatment groups compared to IgG control (p = 0.30 for anti-PD-1 and p = 0.09 for anti-IL-10) did not reach statistical significance (Fig. 5 B).

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