Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.

However, despite being previously published to improve blood glucose in db/db mice [ 10 ], 0.15 % NEN in the current study did not affect blood glucose control or any of the parameters measured apart from a slight trend for mildly decreased gonadal fat pad mass and liver triglyceride content.

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For instance, in both the present study in females and our previous study in males, the low dose of 0.1 % BAM15 resulted in improvements in glucose tolerance and insulin levels that were strikingly similar to those of calorie restriction, as both treatments partially improved glucose tolerance and showed a trend for increased plasma insulin levels.

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