Optimizing antifungal prophylaxis in allogeneic stem cell transplantation: A cohort study of two different approaches.

While the difference in most baseline patient characteristics did not reach statistical significance, cohort 1 did have more patients with a previous IFI, more unrelated donors, a higher median age and more frequent use of ATG, all of which are risk factors for IFI in alloHCT patients and may indicate a higher baseline risk in this group. 4.4 Therapeutic drug monitoring A lower proportion of measured azole concentrations were within the therapeutic range in cohort 1 due to the significant difference in attainment of target azole concentrations in patients who proceeded beyond first‐line antifungal prophylaxis.

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