Subgroup analysis also revealed a favorable trend in change from baseline STS at Week 4 with OC-01 versus vehicle across patient subgroups by randomization stratification factors at baseline ( eFig. 4 ).
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Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial.
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The change from baseline in CFS at Week 4 indicated directional improvements in nasal, temporal and central, as well as a total, score that included all regions, for OC-01 versus vehicle but the differences did not reach statistical significance ( eFig. 2 ).