A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.

While the number of Tregs was decreased post-vaccination (CD4 + , CD25 high , CD27 low ), this decrease did not reach statistical significance ( Figure 1C ). hTERT specificity of T cell response After in vitro overnight stimulation with hTERT, or an irrelevant peptide as control, the proportions of both CD4 + and CD8 + T cells expressing cytokines IL-2 ( p = 0.01, p = 0.02), TNF-α ( p = 0.03/ p = 0.02) and IFN-γ ( p = 0.03/ p = 0.02) increased significantly in response to re-challenge, compared to pre-vaccination levels ( Figure 2 ), but not in response to the irrelevant peptide ( Supplementary Figure S3 ).

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