The data showed a trend towards a higher frequency of recurrent gene alterations (e.g., RB1, PIK3R1) in patients with higher response scores, which suggested intrinsic driving forces of genomic instability.
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Integrative score based on CDK6, PD-L1 and TMB predicts response to platinum-based chemotherapy and PD-1/PD-L1 blockade in muscle-invasive bladder cancer.
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