Connecting atrial fibrillation to digestive neoplasms: exploring mediation via ischemic stroke and heart failure in Mendelian randomization studies.

Conclusion In summary, our findings indicate that AF is a pivotal causal factor in the predisposition to esophageal, colon, and small intestine neoplasms, with IS serving as a mediator in the etiology of colon cancer and HF coordinating similar processes for both esophageal and small intestine malignancies; other associations did not reach statistical significance.

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