IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

At 36 weeks, IL-1β −/− recipients transplanted with VF;IL-1β −/− BM showed a trend toward reduced reticulin fibrosis, reduced GFP chimerism in HSPCs, and partial restoration of splenic architecture ( supplemental Figure 2 C-D), and a trend toward reduction of IL-6 and KC/GRO levels ( supplemental Figure 2 E).

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