Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53^M214K mutants.

In contrast to 18 months of age, tumor incidence at 12 months did not reach statistical significance between mutant genotypes (Fig. 4 C). tert −/− rescues tp53mut reduced lifespan Telomerase deficiency and dysfunctional telomeres result in reduced lifespan 11 – 13 , 15 .

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