highly significantp<0.001
However, in a similar manner a highly significant (Friedman: p<0.001; adj. p (3d post exchange-exchange day <0.001) increase in fibrinogen concentration was observed [median day of exchange: 162g/L (IQR 106/222); median 3d post exchange: 273g/L (IQR 210/389)], following a non-significant (Friedman: p=0.079) decrease ( Figure 5E ) prior to the system exchange.