Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.

In total, four to six biological repetitions confirmed a highly significant downregulation of HCoV-229E infection relative to cell viability for all three FDFT1 and KEAP1 single guide RNAs ( Fig. 3C ).

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While we did not observe a statistically significant effect, knock-out of NFE2L2 showed a trend toward enhanced infection, whereas knock-out of the endogenous inhibitor KEAP1 strongly decreased infection.

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