No differences were observed in OS and PFS in patients with or without EMD, while patients with a previous history of transplantation showed a trend toward a lower 1yr-OS rate (49.4% vs 77.6%). 28 Patients with complex cytogenetics alterations demonstrated a significantly reduced OS and PFS as compared to those patients without these alterations (30% vs. 79% and 25% vs. 64.2%, respectively); in the same way, patients carrying TP53 gene mutations showed a significant lower OS (25% vs. 77.9%).
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