Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study.

Because sedation intensity within the first 48 hours has been shown to increase the hazard of developing delirium ( 28 ), we compared early sedation status between groups: The median RASS on the first study day for patients in standard rooms was lower compared with patients in modified rooms but did not reach statistical significance (–4 [–5 to 0] vs. 0 [–5 to 0], p = 0.0626) ( Fig. 2 ).

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