Early Impairment of Paracrine and Phenotypic Features in Resident Cardiac Mesenchymal Stromal Cells after Thoracic Radiotherapy.

Interestingly, the GO analysis of this set returned several biological process terms with significant adjusted p values, including highly significant terms related to the key fibrotic pathway of TGFβ1 signaling ( Figure 4 b, Supplemental Table S3 ).

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Similarly, the CD45−/CD31+ endothelial-like subpopulation ( Figure 1 d), important for its role in response to injury [ 13 ], displayed a clear trend toward reduction at increasing RT doses, reaching statistical significance between sham and 1.2 Gy.

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