Polystyrene Nano- and Microplastic Particles Induce an Inflammatory Gene Expression Profile in Rat Neural Stem Cell-Derived Astrocytes In Vitro.

The 500 nm particles significantly decreased cell viability in the astrocytes by ~85% at 1000 μg/mL and showed a trend of ~30% decrease at 100 μg/mL ( Figure 2 B, p -value < 0.05).

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Although we only saw a decreasing trend in cell viability in astrocytes exposed to 100 μg/mL of 500 nm PS particles, a total of 1274 DEGs were observed, 505 (39.64%) downregulated and 769 (60.36%) upregulated ( Figure 5 ).

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