ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.

Both genotypes had equivalent input resistance (a measure of neuronal polarization) and had spontaneous action potentials (APs) and trains of action potentials in response to depolarizing current ( Figure 2 C, left and middle); however, homozygous motor neurons trended toward increased AP frequency though this did not reach statistical significance ( Figure 2 C right).

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