Role of human Kallistatin in glucose and energy homeostasis in mice.

At 4 weeks, we observed a moderately higher body fat content in hKST-TG which did not reach statistical significance and disappeared until 25 weeks, and no differences in lean mass (4 weeks: fat content 5.24 ± 0.49% in WT vs. 7.26 ± 0.43% in hKST-TG, P < 0.05, lean mass: 75.05 ± 0.45% in WT vs. 75.00 ± 0.43% in hKST, P = 0.97; 24 weeks: fat content 14.21 ± 0.66% in WT vs. 14.82 ± 0.78% in hKST-TG, P = 0.47, lean mass: 67.08 ± 0.77% in WT vs. 65.89 ± 1.56% in hKST, P = 0.69).

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