Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors.

In the univariate analysis in the chemoimmunotherapy cohort, CD8-high ( P = 0.0060) showed a significant association with PFS, while ECOG-PS ≥ 1 ( P = 0.0014) and SCLC-P (vs SCLC-I) ( P = 0.037) had an unfavorable association, and clinical stage (C-Stage ≥ IVB) ( P = 0.070) and SCLC-N (vs SCLC-I) ( P = 0.068) showed an unfavorable trend with PFS (Table 2 ).

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