Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice.

The amount of BNIP3 was higher in islets isolated from metformin-treated db/db mice than in those from imeglimin-treated db/db mice, but this did not reach statistical significance, possibly due to the high variability.

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