Unlike the other experimental conditions, the Rheb Y35L condition displayed a slight decrease in sEPSC frequency, consistent with previous findings in Rheb S16H neurons; however, this did not reach statistical significance ( Figure 4b ).
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The mTOR pathway genes <i>MTOR</i>, <i>Rheb</i>, <i>Depdc5</i>, <i>Pten</i>, and <i>Tsc1</i> have convergent and divergent impacts on cortical neuron development and function.
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