METTL3-mediated HPV vaccine enhances the effect of anti PD-1 immunotherapy to alleviate the development of cutaneous squamous cell carcinoma.

32 Overexpression of METTL3 followed by treatment with PD-1 monoclonal antibodies did not show a significant trend of tumor regression in the present results, whereas the HPV vaccine has the potential to act as a METTL3 inhibitor, and the combination with PD-1 monoclonal antibodies for cSCC played a synergistic role to further slowdown the tumor growth.

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