Untargeted metabolomics uncovers metabolic dysregulation and tissue sensitivity in ACE2 knockout mice.

In HFD-fed ACE2 mice, the altered metabolites were also enriched in several metabolism related to steroid hormone metabolism, but thesis did not reach statistical significance, This included 4 pathways (cortisol synthesis and secretion, aldosterone synthesis and secretion, ovarian steroidogenesis, and steroid hormone biosynthesis) in serum, 4 pathways (aldosterone synthesis and secretion, steroid hormone biosynthesis, cortisol synthesis and secretion and aldosterone-regulated sodium reabsorption) in liver, and 3 pathways (aldosterone-regulated sodium reabsorption, steroid hormone biosynthesis and aldosterone synthesis and secretion) in muscle.

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