Trends in Syphilis in Pregnant Women in Japan in 2016 and 2022.

The decreases in the incidence of perinatal mortality and congenital syphilis did not reach statistical significance (p = 0.43 and 0.07, respectively).

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Conclusions The prevalence of syphilis-infected pregnant women increased significantly in 2022 compared with that in 2016 in Japan; however congenital infection of syphilis did not increase, but rather showed a decreasing trend.

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